Epitope mapping of the major allergen 2S albumin from pine nut

The epitopes of the major allergen pine nut, Pin p 1, were analyzed using a peptide library and sera from patients with clinical allergy to nut in order deepen into allergenic characteristics 1. Analyses epitope similarities location 3D-model also performed. Results showed that three main regions 1 containing 5 recognized by patient IgE. had important 2S albumins peanut (Ara h 2 6) Brazil (Ber e 1). found ?-helices coils 3D protein structure. Interestingly, all be well-exposed surface, which suggests facile access for IgE-binding structure is known highly resistant.